One of the pieces of advice that I've read a dozen times (probably a LOT more), is that when it's time to get other readers to look over your work, you should NEVER let your friends or family do it. After all, they don't want to hurt your feelings, and they'll simply look it over and tell you how great it is, how proud of you they are, and possibly that they don't understand exactly what you're writing, so they can't give you great advice on how to make it better, but they really enjoyed it.
I disagree. At least with my friends. The people I spend my time with are completely honest with me. My buddy Justin and I were talking about my book just yesterday, and he said matter-of-factly that he would never read it before it got published simply because I "can't handle how cruel he is when editing". I told him he's wrong. I don't expect him to read my book and help me edit it, but over the past three or four years, I've learned to separate myself from my work in a way that lets me actually listen to the critiques other people give me. And if I don't agree with a note they give me (like if they are the only person who noticed something out of place, and their opinion directly opposes the opinions of several other critiquing partners), then I know how ignore it without skewing my view of my friends.
I think it's important that you trust the people who read your work, whether they're other writers you met through a workshop, or readers you met through forums, but especially when they're your family and friends. If you know they're not going to give you useful advice, then don't let them critique your work. But if you value their opinion, and if they're willing to tear your writing to shreds so that you'll be able to improve it, then by all means, ask for their help. Just don't take it personally if they tell you something that you don't want to hear. After all, if they really are your friends, they want to see you succeed.